Table 2.
Proteomic analyses of selected down-regulated proteins in LTLT-Ca letrozole-resistant mammospheres where ratios (3D/2D) of the fold changes and p values are shown.
| Accession | Description | # AAs | MW [kDa] | Fold change (3D/2D) | t-test (p values) |
|---|---|---|---|---|---|
| IPI00013485.3 | 40S ribosomal protein S2 | 293 | 31.3 | -1.704 | 7.75E-05 |
| IPI00012750.3 | 40S ribosomal protein S25 | 125 | 13.7 | -1.780 | 4.94E-06 |
| IPI00221091.9 | 40S ribosomal protein S15a | 130 | 14.8 | -1.784 | 2.22E-04 |
| IPI00216514.6 | Isoform OA3-293 of Leukocyte surface antigen CD47 | 292 | 31.7 | -1.784 | 4.89E-05 |
| IPI00647168.1 | Ribosomal protein L11 | 131 | 14.9 | -1.703 | 1.29E-04 |
| IPI00215780.5 | 40S ribosomal protein S19 | 145 | 16.1 | -1.782 | 2.92E-04 |
| IPI00026271.5 | 40S ribosomal protein S14 | 151 | 16.3 | -1.746 | 6.69E-05 |
| IPI00908521.1 | Isoform 2 of Brain acid soluble protein 1 | 173 | 17.7 | -1.673 | 2.78E-03 |
| IPI00644936.1 | Isoform 3 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | 379 | 44.2 | -2.055 | 2.63E-05 |
| IPI00926712.1 | Integrin beta | 681 | 74.9 | -2.021 | 3.96E-08 |
| IPI00011253.3 | 40S ribosomal protein S3 | 243 | 26.7 | -1.849 | 1.43E-04 |
| IPI00019472.4 | Neutral amino acid transporter B(0) | 541 | 56.6 | -2.039 | 8.05E-06 |
| IPI00979226.1 | 60S ribosomal protein L17 isoform b | 146 | 17.1 | -2.004 | 8.59E-05 |
| IPI00337335.8 | Isoform 1 of Myosin-14 | 1995 | 227.7 | -1.967 | 7.32E-05 |
| IPI00922108.2 | integrin alpha-V isoform 2 | 1002 | 111.1 | -2.111 | 8.17E-06 |
| IPI00645589.1 | Isoform 3 of Choline transporter-like protein 2 | 704 | 79.8 | -2.089 | 5.47E-05 |
| IPI00985384.1 | ATP-dependent RNA helicase DDX3X isoform 3 | 646 | 71.3 | -2.194 | 6.26E-05 |
| IPI00008438.1 | 40S ribosomal protein S10 | 165 | 18.9 | -2.337 | 5.48E-07 |
| IPI00396321.1 | Leucine-rich repeat-containing protein 59 | 307 | 34.9 | -2.144 | 5.22E-05 |
| IPI00015842.1 | Reticulocalbin-1 | 331 | 38.9 | -2.136 | 2.76E-04 |
| IPI00221088.5 | 40S ribosomal protein S9 | 194 | 22.6 | -2.467 | 7.90E-04 |
| IPI00455315.4 | Isoform 1 of Annexin A2 | 339 | 38.6 | -2.496 | 5.64E-05 |
| IPI00009865.4 | Keratin, type I cytoskeletal 10 | 584 | 58.8 | -2.176 | 7.64E-02 |
| IPI00297910.2 | Tumor-associated calcium signal transducer 2 | 323 | 35.7 | -3.207 | 9.52E-06 |