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. 2021 Feb 1;8(3):592–602. doi: 10.1002/acn3.51301

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© 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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P‐syn deposited in skin nerve fibers of PD patients with and without G2385R variant. Double immunofluorescent staining demonstrated linear or dotted p‐syn immunosignals (green) colocalized with PGP9.5 signals in DB in deep dermis (A–C), nerve fibers innervating SG (D–F), APM (G–I), and SP and DB (asterisk) in superficial dermis (J–L). P‐syn, phosphoralated α synuclein; Arrows indicated p‐syn immunosignals; DB, dermal nerve bundles, SG, nerve fibers innervating sweat glands, APM, arrector pili muscles; SP, subepidermal plexus; PD, Parkinson disease. Scale bar: 50 μm.