Table 1.
Baseline characteristics of the study participants according to plasma ANGPTL‐4 levels.
| Characteristics | Total | ANGPTL‐4, ng/mL | P value | ||
|---|---|---|---|---|---|
| <78.7 | 78.7–112.9 | ≥112.9 | |||
| No. of subjects | 3379 | 1073 | 1159 | 1147 | |
| Demographics | |||||
| Age, years | 62.3 (10.9) | 59.6 (9.7) | 61.8 (10.7) | 65.39 (11.2) | <0.001 |
| Male | 2154 (63.8) | 639 (59.6) | 725 (62.6) | 790 (68.9) | <0.001 |
| Current cigarette smoking | 1237 (36.6) | 396 (36.9) | 437 (37.7) | 404 (35.2) | 0.400 |
| Current alcohol drinking | 1063 (31.5) | 346 (32.3) | 367 (31.7) | 350 (30.5) | 0.378 |
| Medical history | |||||
| History of hypertension | 2657 (78.6) | 826 (77.0) | 917 (79.1) | 914 (79.7) | 0.123 |
| History of hyperlipidemia | 243 (7.2) | 73 (6.8) | 87 (7.5) | 83 (7.2) | 0.701 |
| History of diabetes mellitus | 599 (17.7) | 150 (14.0) | 215 (18.6) | 234 (20.4) | <0.001 |
| Family history of stroke | 637 (18.9) | 199 (18.6) | 237 (20.5) | 201 (17.5) | 0.517 |
| Clinical features | |||||
| NIHSS score | 4 (2–8) | 4 (2–6) | 4 (2–7) | 6 (3–10) | <0.001 |
| SBP, mmHg | 166 (17) | 164 (16) | 166 (17) | 168 (18) | <0.001 |
| DBP, mmHg | 97 (11.01) | 97 (10) | 97 (11) | 97 (11) | 0.819 |
| BMI, kg/m2 | 24.9 (3.1) | 24.8 (3.1) | 25.1 (3.1) | 24.9 (3.1) | 0.834 |
| Fasting blood glucose, mmol/L | 5.8 (5.1–7.2) | 5.5 (4.9–6.7) | 5.8 (5.0–7.3) | 6.0 (5.3–7.7) | <0.001 |
| TG, mmol/L | 1.5 (1.0–2.2) | 1.5 (1.1–2.3) | 1.5 (1.1–2.2 | 1.4 (1.0–2.0) | 0.156 |
| TC, mmol/L | 5.0 (4.3–5.7) | 4.9 (4.2–5.6) | 5.0 (4.3–5.7) | 5.1 (4.3–5.9) | <0.001 |
| LDL‐C, mmol/L | 2.9 (2.3–3.5) | 2.8 (2.2–3.3) | 2.9 (2.3–3.5) | 2.9 (2.3–3.6) | 0.002 |
| HDL‐C, mmol/L | 1.2 (1.0–1.5) | 1.2 (1.0–1.5) | 1.2 (1.0–1.5) | 1.2 (1.0–1.5) | 0.807 |
| Ischemic stroke subtype | |||||
| Thrombotic | 2642 (78.2) | 663 (77.7) | 644 (75.5) | 685 (76.6) | 0.303 |
| Embolic | 164 (4.9) | 38 (4.5) | 44 (5.1) | 44 (5.1) | 0.280 |
| Lacunar | 655 (19.4) | 173 (20.3) | 190 (22.3) | 146 (17.1) | 0.221 |
Continuous variables are expressed as mean (standard deviation), or as median (interquartile range). Categorical variables are expressed as frequency (percent). ANGPTL‐4: 95.3 (71.4–126.5) ng/mL. ANGPTL‐4, angiopoietin‐like protein 4; SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; TG, triglycerides; TC, total cholesterol; LDL‐C, low‐density lipoprotein cholesterol; HDL‐C, high‐density lipoprotein cholesterol; NIHSS, National Institute of Health Stroke Scale.