Table 4.
Subgroup analysis of adjusted ORs (95% CI) of primary outcome according to plasma ANGPTL‐4 tertiles.
| Characteristics | ANGPTL‐4, ng/mL | Each SD increase in log‐ANGPTL‐4 | P interaction | |||
|---|---|---|---|---|---|---|
| <78.7 | 78.7–112.9 | ≥112.9 | P trend | |||
| Sex | ||||||
| Male | 1.00 | 1.58 (1.12–2.23) | 1.86 (1.33–2.60) | 0.011 | 1.29 (1.13–1.48) | 0.413 |
| Female | 1.00 | 1.69 (1.13–2.54) | 2.10 (1.38–3.21) | 0.010 | 1.41 (1.20–1.67) | |
| Age, years | ||||||
| <65 | 1.00 | 1.69 (1.18–2.42) | 1.72 (1.23–2.41) | 0.014 | 1.29 (1.11–1.49) | 0.100 |
| ≥65 | 1.00 | 1.39 (0.92–2.09) | 1.87 (1.26–2.76) | <0.001 | 1.28 (1.10–1.49) | |
| Baseline SBP, mmHg | ||||||
| <160 | 1.00 | 1.54 (0.99–2.41) | 1.86 (1.18–2.94) | 0.008 | 1.23 (1.03–1.47) | 0.054 |
| ≥160 | 1.00 | 1.53 (1.10–2.12) | 1.55 (1.11–2.16) | 0.013 | 1.24 (1.09–1.42) | |
| Body mass index, kg/m2 | ||||||
| <24 | 1.00 | 1.87 (1.24–2.81) | 2.29 (1.53–3.44) | <0.001 | 1.30 (1.12–1.52) | 0.250 |
| ≥24 | 1.00 | 1.26 (0.87–1.81) | 1.29 (1.01–1.83) | 0.034 | 1.17 (1.01–1.37) | |
| Dyslipidemia | ||||||
| No | 1.00 | 1.78 (1.20–2.64) | 2.02 (1.37–2.96) | 0.007 | 1.25 (1.08–1.45) | 0.224 |
| Yes | 1.00 | 1.15 (0.80–1.67) | 1.50 (1.04–2.17) | 0.020 | 1.22 (1.05–1.43) | |
| Cigarette smoking | ||||||
| No | 1.00 | 1.38 (1.01–1.91) | 1.69 (1.22–2.34) | 0.001 | 1.27 (1.11–1.45) | 0.088 |
| Yes | 1.00 | 1.48 (0.91–2.40) | 1.77 (1.11–2.83) | 0.034 | 1.18 (0.98–1.42) | |
| Current alcohol drinking | ||||||
| No | 1.00 | 1.37 (1.01–1.87) | 1.68 (1.22–2.30) | 0.001 | 1.25 (1.10–1.41) | 0.792 |
| Yes | 1.00 | 1.45 (0.86–2.44) | 2.03 (1.23–3.37) | 0.019 | 1.18 (0.95–1.45) | |
| Fasting plasma glucose, mmol/L | ||||||
| <7 | 1.00 | 1.63 (1.19–2.24) | 1.69 (1.25–2.29) | 0.004 | 1.25 (1.10–1.41) | 0.524 |
| ≥7 | 1.00 | 1.23 (0.74–2.05) | 1.58 (0.96–2.58) | 0.046 | 1.18 (0.97–1.47) | |
| Receiving immediate BP reduction | ||||||
| No | 1.00 | 1.24 (0.85–1.80) | 1.42 (0.96–2.08) | 0.075 | 1.17 (1.01–1.36) | 0.190 |
| Yes | 1.00 | 1.82 (1.25–2.65) | 1.84 (1.26–2.68) | 0.002 | 1.30 (1.12–1.51) | |
In the multivariate models, confounding factors such as age, sex, hospital location (by province), antihypertensive treatment, time from onset to hospitalization, current smoking, current alcohol drinking, body mass index, dyslipidemia, fasting blood glucose, history of hypertension, history of diabetes mellitus, family history of stroke, SBP at baseline, ischemic stroke subtypes and baseline NIHSS score were included unless the variable was used as a subgroup variable. ORs, odds ratios; CI, confidence interval; ANGPTL‐4, angiopoietin‐like protein 4; SBP, systolic blood pressure.