TABLE 1.

Cargos in exosomes derived from OSCC.

Biomolecules	Function	Molecules	Exosome origin	References
miRNAs	Suppressor	miR-338, miR-24-3p, miR-891a, miR-106a-5p, miR-2a-5p, miR-1908, miR-101-3p	Cell lines	Ye et al., 2014; Tachibana et al., 2016; Xie et al., 2019a
	Biomarker	miR-223	Plasma	Tachibana et al., 2016
	Metastasis	miR-21, miR-142-3p, miR-29a-3p, miR-342-3p, miR-1246, miR-200c-3p	Cell lines	Sakha et al., 2016; Dickman et al., 2017; Liu et al., 2017; Kawakubo-Yasukochi et al., 2018; Cai et al., 2019
	Accumulation of fibronectin	miR-382-5p, miR-34a-5p, miR-3188	CAFs	Bovy et al., 2015; Liu et al., 2017; Li et al., 2018
	Motility	miR-342-3p, miR-1246,	Cell lines	Sakha et al., 2016
	Angiogenesis	miR-21	Cell lines	Momen-Heravi and Bala, 2018
	Immune regulation	miR-138,	Cell lines	Xie et al., 2019a
Proteins	Biomarker	PF4V1, CXCL7, F13A1, ApoA1	Serum	Li et al., 2019a
		VEGF, EGFR, HSPs	OSCC cells	Fujiwara et al., 2018; Ono et al., 2018; Rosenberger et al., 2019
lncRNAs	Proliferation	Lnc-FLJ22447	OSCC cells	Ding et al., 2018

CAFs, cancer-associated fibroblasts; HSPs, heat shock proteins; EGFR, epidermal growth factor receptor; VEGF, vascular endothelial growth factor; PF4V1, platelet factor 4 variant 1; CXCL7, C-X-C motif chemokine ligand 7; F13A1, coagulation factor XIII A chain; ApoA1, apolipoprotein A1.