Table 2.

Level of association of clinical factors at baseline with clinical treatment failure from the univariate analyses (follow‐up assessment clinically evaluable population)

Clinical factor	Odds ratio (OR)	95% confidence interval (CI)	P value
White blood cell count	1·80	1·39–2·32	<0·001
C‐reactive protein	1·74	1·31–2·31	<0·001
Baseline severity by UT* score (severe versus moderate)	2·40	1·37–4·19	0·002
Erythrocyte sedimentation rate	1·48	1·13–1·93	0·004
Total wound score	1·51	1·14–1·98	0·004
Outpatient (initial treatment inpatient versus outpatient)	2·14	1·23–3·72	0·007
Serum albumin	0·52	0·33–0·83	0·007
Gender (male versus female)	1·95	1·06–3·60	0·032
Dermal thermometry (≥10°C versus <10°C)	2·21	1·04–4·70	0·040
Serum glucose	1·23	0·95–1·59	0·112
Previous insulin use (yes versus no)	1·59	0·89–2·85	0·121
Wound onset duration (>6 months versus ≤6 months)	1·67	0·80–3·48	0·169
Treatment arm (piperacillin/tazobactam versus ertapenem)	1·45	0·84–2·53	0·185
Haemoglobin	0·85	0·64–1·12	0·243
Nylon monofilament test (≥2 versus 0–1)	1·46	0·73–2·94	0·290
Body mass index	0·86	0·64–1·17	0·335
Serum creatinine	0·79	0·43–1·45	0·454
Systolic blood pressure	0·91	0·69–1·20	0·507
Dorsalis pedis pulse (0 to 1+ versus >1+)	0·85	0·47–1·54	0·597
Foot X ray (abnormal versus normal)	1·08	0·61–1·93	0·785
Diastolic blood pressure	0·97	0·74–1·278	0·833
Haemoglobin A1C	1·03	0·756–1·39	0·875
Duration of diabetes diagnosis	1·02	0·78–1·34	0·876
Age	0·98	0·75–1·29	0·902
Weight	0·99	0·75–1·31	0·937

^* UT = University of Texas wound classification. Single logistic regression was used to estimate the OR, 95% CI and P values. OR for the continuous variables represent the increased odds of clinical failure based on a 1 standard deviation increase in the risk factor.