Treatment of the underlying cause |
e.g. diabetes, hypertension and sickle cell disease |
Local therapy |
Debridement (enzymatic and surgical) |
Antibiotics and antiseptics |
Skin grafts – split skin grafts, mesh grafts, pinch grafts and homologous keratinocytes |
Growth factors |
Pharmacological therapy – stanozolol, oxpentifylline, aspirin and thrombolytics |
Compression therapy |
High compression elastic bandages |
Grade I = 20 mm of Hg |
High compression inelastic bandages |
Grade II = 21–30 mm of Hg |
Multi‐layer compression bandages |
Grade III = 31–40 mm of Hg |
Short‐stretch bandages |
Grade IV = 41–60 mm of Hg |
Unna's boot |
Surgery |
Ulcer debridement, excision or grafting |
Varicose veins surgery, perforator ligation stripping and avulsions |
Venous valve reconstruction/replacement, venous by‐pass surgery |