Table 2.
Granulation response to treatment with intra‐lesional rhEGF
| Group I (N = 53) | Group II (N = 48) | Group III (N = 48) | P (χ2 test) | |
|---|---|---|---|---|
| After 2 weeks of treatment | ||||
| Complete + partial response (≥ 50% granulation) | 44 (83·1%) | 34 (70·8%) | 19 (39·6%) | 0·000015 |
| Difference versus control group (95% CI) | 43·8 (24·3;62·6) | 31·2 (10·3;52·2) | ||
| Odds ratio (95% CI) | 7·5 (2·9;18·9) | 3·7 (1·6;8·7) | ||
| After the end of treatment | ||||
| Complete response (> 75% granulation) | 46 (86·8%) | 34 (70·8%) | 28 (58·3%) | 0·005 |
| Difference versus control group (95% CI) | 28·5 (9·8;47·1) | 12·5 (− 8·6;33·6) | ||
| Odds ratio (95% CI) | 4·7 (1·8;12·5) | 1·7 (0·7;4·0) | ||
| Weeks to complete response (median; 95% CI) P versus group III (log rank test) | 3 (2·6–3·4) P = 0·006 | 3 (2·3–3·7) P = 0·031 | 5 (3·2–6·8) | |