Table 5.

Adverse events frequency

Events	Group I n = 53	Group II n = 48	Group III n = 48
Subjects with any adverse event	37 (69·8%)	28 (58·3%)	31 (64·5%)
Severe
Infection	4	4	2
Other	Renal failure Cellulitis	Renal failure (lethal) Myocardial infarct Pneumonia	Acute pulmonary oedema (2; 1 lethal) Cellulitis Knee abscess
Mild or moderate (occurring in 10 patients or more)
Pain at the administration site	13 (24·5%)	13 (27·1%)	20 (41·7%)
Burning sensation	12 (22·6%)	10 (20·8%)	14 (29·2%)
Shivering	17 (32·1%)	8 (16·7%)	2 (4·2%)
Local infection	3 (5·7%)	4 (8·3%)	7 (18·8%)
Chills	11 (20·8%)	4 (8·3%)	1 (2·1%)
Anaemia	4 (7·5%)	3 (6·3%)	5 (10·4%)
Fever	2 (3·8%)	4 (8·3%)	6 (12·5%)
Nauseas	4 (7·5%)	1 (2·1%)	2 (4·2%)
Vomits	3 (5·7%)	2 (4·2%)	1 (2·1%)