Table 3.

NPWT/ROCF systems: contraindications, warnings and precautions recommended by the panel ^*

CONTRAINDICATIONS	WARNINGS	PRECAUTIONS
Gross infection	If bleeding develops, discontinue therapy	Exposed blood vessels, nerves or organs must be protected using overlying fascia, tissue, or other protective barrier
Sepsis	Protect vessels and organs (cover with thick layers of natural tissue or meshed non‐adherent material)	Extreme care must be taken in the presence of existing or potential bleeding problems
Recurrent deep wound infection	Use therapy cautiously in presence of infected blood vessels	Bone fragments or sharp edges that could puncture protective barriers, vessels, or organs should be managed by debriding sharp edges
Presence of a pseudoaneurysm	Smooth and cover any residual sharp edges to decrease risk of serious or fatal injury	Extreme care must be taken to protect vascular anastomoses, including coronary artery bypass grafts, or weakened, irradiated, or sutured blood vessels or organs
Malignancy	Monitor hemostasis, anticoagulants, and platelet aggregation inhibitors
Lack of local wound hemostasis	Monitor infected wounds closely; may require more frequent dressing changes than non‐infected wounds
Untreated osteomyelitis	NPWT/ROCF‐silver is not intended to replace use of systemic therapy
Unprotected vascular anastomoses
Foam placement directly over weakened or irradiated vessels

^* This table does not necessarily reflect the contraindications, warnings, and precautions provided in the manufacturer's labeling.