. 2007 Jul 21;4(2):124–137. doi: 10.1111/j.1742-481X.2007.00314.x

Table 3.

Acquired resistance to antiseptics used in wound care

Agent	First clinical use	Resistance	Organisms
Honey	Antiquity	ND	ND
Silver	19th century	1970s	Pseudomonas aeruginosa
Silver	19th century	1970s	Enterobacteriaceae
Iodine	1839	ND^*	ND^*
Hydrogen peroxide	1887	ND	ND
Quaternary ammonium compounds	1993	1951	Ps. aeruginosa
Chlorhexidine	1954	1967	Proteus mirabilis
Chlorhexidine	1954	1990s	Staphylococci
Triclosan	1970s	1998	Ps. aeruginosa

ND, not detected.

There was a single report of resistance for MRSA in 1985 but of questionable methodology (21).