Table 3.
Agent | First clinical use | Resistance | Organisms |
---|---|---|---|
Honey | Antiquity | ND | ND |
Silver | 19th century | 1970s | Pseudomonas aeruginosa |
Enterobacteriaceae | |||
Iodine | 1839 | ND* | ND* |
Hydrogen peroxide | 1887 | ND | ND |
Quaternary ammonium compounds | 1993 | 1951 | Ps. aeruginosa |
Chlorhexidine | 1954 | 1967 | Proteus mirabilis |
1990s | Staphylococci | ||
Triclosan | 1970s | 1998 | Ps. aeruginosa |
ND, not detected.
There was a single report of resistance for MRSA in 1985 but of questionable methodology (21).