Fig 2. Population dynamics of Killer-Rescue/Cargo, ClvR and split^50cM ClvR V2.

Drive with split ClvR with independent segregation (split^<50cM ClvR) is stronger than that of Killer-Rescue in the absence or presence of fitness costs. (A-F, and J-O) Plotted are genotype frequencies for Rescue/Cargo and Cas9, and allele frequencies for LOF (y-axis) over generations (x-axis). Release percentages are 10% (yellow), 20% (blue), 30% (green), 40% (red), and 60% (orange). (A-F) elements have no fitness costs; (G-L) 5% additive fitness cost/allele. In panels G-L there is a 50% release percentage of WT in generation 150 (dotted lines).