Fig 1. General CISNET-Cervical model schematic.

Both CISNET-Cervical models capture distinct phases of the disease process and interventions, including HPV transmission, cervical cancer natural history, HPV vaccination, and cervical screening, diagnosis, and treatment but differ with respect to the number of health states, HPV genotype categorization, histological cancer types, and data sources used to parameterize the baseline model prior to model calibration to the US setting (Table A in S1 Text). Disease progression in the model is characterized as a sequence of monthly transitions between health states that are descriptive of each patient’s underlying true health, including infection status, grade of CIN, and stage of cancer. CIN, cervical intraepithelial neoplasia; CISNET, Cancer Intervention and Surveillance Modeling Network; HPV, human papillomavirus.