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. 2021 Mar 11;16(3):e0245193. doi: 10.1371/journal.pone.0245193

Table 3. Adjusted cause-specific hazard ratios of time-dependent continuity of care calculated with all outpatient family physician and specialist visits (COC using ≥ 2 visits annually).

Condition 1 (n = 166,665) to Condition 2 Condition 2 (n = 119,520) to Condition 3 Condition 3 (n = 68,021) to Condition 4
Characteristic CHR 95% CI p-value CHR 95% CI p-value CHR 95% CI p-value
Continuity of care
    Low (≤ 0.71) Reference - - Reference - - Reference - -
    High (> 0.71) 0.91 (0.90 to 0.93) <0.0001 0.91 (0.89 to 0.93) <0.0001 0.93 (0.91 to 0.96) <0.0001
    <2 visits 0.75 (0.74 to 0.76) <0.0001 0.67 (0.65 to 0.69) <0.0001 0.68 (0.64 to 0.71) <0.0001
Age (years)
    18 to 24 Reference - - Reference - - Reference - -
    25 to 29 1.09 (1.05 to 1.13) <0.0001 1.22 (1.10 to 1.36) <0.0001 1.49 (1.07 to 2.07) 0.017
    30 to 34 1.24 (1.20 to 1.30) <0.0001 1.34 (1.21 to 1.50) <0.0001 1.54 (1.12 to 2.11) <0.0001
    35 to 39 1.44 (1.39 to 1.50) <0.0001 1.61 (1.46 to 1.78) <0.0001 1.98 (1.45 to 2.71) <0.0001
    40 to 44 1.62 (1.57 to 1.68) <0.0001 1.79 (1.62 to 1.97) <0.0001 2.46 (1.80 to 3.36) <0.0001
    45 to 49 1.92 (1.86 to 1.99) <0.0001 2.18 (1.98 to 2.41) <0.0001 2.78 (2.04 to 3.79) <0.0001
    50 to 54 2.21 (2.13 to 2.29) <0.0001 2.46 (2.23 to 2.71) <0.0001 3.18 (2.34 to 4.34) <0.0001
    55 to 59 2.42 (2.34 to 2.51) <0.0001 2.69 (2.44 to 2.97) <0.0001 3.48 (2.56 to 4.74) <0.0001
    60 to 64 2.73 (2.63 to 2.83) <0.0001 3.02 (2.74 to 3.33) <0.0001 3.86 (2.84 to 5.26) <0.0001
    65 to 69 3.03 (2.91 to 3.14) <0.0001 3.26 (2.95 to 3.60) <0.0001 4.25 (3.12 to 5.79) <0.0001
    70 to 74 3.22 (3.10 to 3.35) <0.0001 3.51 (3.17 to 3.87) <0.0001 4.73 (3.47 to 6.44) <0.0001
    75 to 79 3.54 (3.40 to 3.70) <0.0001 3.90 (3.52 to 4.31) <0.0001 5.27 (3.86 to 7.18) <0.0001
    ≥ 80 3.80 (3.65 to 4.00) <0.0001 4.43 (4.01 to 4.90) <0.0001 6.27 (4.61 to 8.54) <0.0001
Sex
    Male Reference - - Reference - - Reference - -
    Female 1.01 (1.00 to 1.02) 0.058 0.97 (0.95 to 0.99) 0.0006 0.90 (0.88 to 0.93) <0.0001
Residence
    Rural Reference - - Reference - - Reference - -
    Urban 1.04 (1.02 to 1.06) <0.0001 1.02 (1.00 to 1.05) 0.11 0.99 (0.95 to 1.03) 0.47
Neighborhood income quintile
    Quintile 1 (lowest income) Reference - - Reference - - Reference - -
    Quintile 2 0.96 (0.95 to 0.98) <0.0001 0.95 (0.92 to 0.98) 0.0002 0.95 (0.92 to 0.99) 0.019
    Quintile 3 0.94 (0.92 to 0.95) <0.0001 0.94 (0.91 to 0.96) <0.0001 0.94 (0.90 to 0.98) 0.0016
    Quintile 4 0.92 (0.90 to 0.94) <0.0001 0.93 (0.90 to 0.95) <0.0001 0.94 (0.90 to 0.98) 0.0021
    Quintile 5 (highest income) 0.91 (0.89 to 0.92) <0.0001 0.90 (0.87 to 0.92) <0.0001 0.91 (0.87 to 0.95) <0.0001
Primary care enrolment model
    Not-Enrolled Reference - - Reference - - Reference - -
    Family Health Group 1.11 (1.09 to 1.14) 0.63 1.01 (0.98 to 1.03) 0.54 1.03 (0.99 to 1.06) 0.15
    Family Health Network or Organization 1.04 (1.02 to 1.07) <0.0001 0.94 (0.91 to 0.97) <0.0001 0.96 (0.92 to 1.01) 0.09
    Family Health Team 1.02 (0.99 to 1.05) <0.0001 0.93 (0.90 to 0.96) <0.0001 0.93 (0.89 to 0.97) 0.0019
    Other 1.13 (1.08 to 1.18) 0.27 1.03 (0.98 to 1.08) 0.24 1.04 (0.97 to 1.11) 0.26
Outpatient general practice visits 1.13 (1.11 to 1.12) <0.0001 1.11 (1.11 to 1.12) <0.0001 1.09 (1.08 to 1.09) <0.0001
Outpatient specialist visits 1.13 (1.10 to 1.17) <0.0001 1.09 (1.06 to 1.12) <0.0001 1.12 (1.08 to 1.16) <0.0001

Abbreviations: CI = Confidence Interval; CHR = Cause-Specific Hazard Ratio.

Note: The relationship between continuity and a) Time in days until the diagnosis of the 2nd condition among those with at least 1 condition (n = 166,665), b) Time in days until the diagnosis of the 3rd condition among those with at least 2 conditions (n = 119,520), and c) Time in days until the diagnosis of the 4th condition among those with at least 3 conditions (n = 68,021) was estimated with multivariable cause-specific hazards regression models. The effect estimate of continuity was adjusted for age, sex, neighborhood income, primary care enrolment model, number of physician visits (outpatient general practice, outpatient specialist), and place of residence simultaneously.

‡Continuity of care was measured using the Bice-Boxerman Index and categorized as high versus low continuity at the median among all patients at index. All visits to family physicians and specialists in outpatient settings (office, home, long-term care, emergency department, telephone, ‘undefined’) in the previous year were counted in the calculation of continuity.

†Comprehensive Care Model, Community Sponsored Agreement, Community Health Group, Group Health Center, Health Services Organization, Primary Care Network, Rural and Northern Group, South Eastern Area Medical Organization, and St. Joseph’s Health Centre.