Table 2:

Comparison of metabolic properties of LSCs vs. solid tumor CSCs

CSC Type	Metabolism relative to LSCs	Metabolic Flexibility Compared to LSCs
Glioblastoma	Similarities Reliance on OXPHOS for CSC activity80 Differences Increased oxidative capacity and ATP levels, some GSCs are reliant on glycolysis for CSC activity79,96	Similarities Metabolically unique CSC populations within same tumor sample, certain GSCs reliant on fatty acid metabolism97,98,99 Differences *Switch from OXPHOS to glycolysis occurs during metabolic stress96,97,98
Breast Cancer	Similarities Decreased CSC activity upon mitochondrial metabolism inhibition84 Differences Increased mitochondrial membrane potential and ATP levels83	Similarities Increased OXPHOS activity and reliance on fatty acid metabolism in CSCs from chemo-resistant samples85,86,101 Differences Some BCSCs reliant on glycolysis100
Ovarian Cancer	Similarities Not reliant on glycolysis for CSC activity, decreased CSC activity upon mitochondrial metabolism inhibition87 Differences Increased mitochondrial membrane potential87	Similarities Increased metabolic demands upon chemotherapy resistance102 Differences *OXPHOS inhibition induces compensatory glycolysis, increased pentose phosphate pathway activity103
Pancreatic Cancer	Similarities Decreased CSC activity upon OXPHOS inhibition90 Differences *Increased OCR and mitochondrial membrane potential89	Similarities Ability to metabolically reprogram upon chemotherapy treatment104 Differences Decreased CSC activity upon glycolysis inhibition, glycolysis inhibition re-sensitizes to chemotherapeutic agents104
Colorectal Cancer	Similarities Decreased ROS levels, reliance on AMPK for CSC activity91 Differences Increased levels of S-Adenosyl Methionine106	Similarities Increased mitochondrial metabolism in chemotherapy resistant CSCs, metabolic reprogramming upon chemotherapy exposure92,93,106 Differences *Increased lysine metabolism upon chemotherapy treatment108