Figure 1.

A, Infection of rhesus (Rh) macaques and cynomolgus (Cyno) macaques by SARS-CoV-2, and sample collection. Viral loads and systemic factors were quantified before infection (day −9 represents the basal line) and at different time points post-infection. Feces samples, but not other samples, were collected the day of infection (day 0). B, Viral loads (measured in an RT-qPCR assay) in nasopharyngeal swabs, tracheal swabs, and rectal swabs. The estimated limit of detection was 2.3 log10 copies of SARS-CoV-2 RNA per ml, and the estimated limit of quantification was 3.9 log10 copies per ml (dotted horizontal line); C, The plasma CRP concentration. D, Cytokine and chemokine concentrations in plasma. B-D, The time course analysis for each animal (n = 4). Basal line was adjusted to day 0 on the graphs