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. 2021 Mar 1;17(3):e1009368. doi: 10.1371/journal.ppat.1009368

Fig 4. The Pikh-HMA domain adopts a favourable conformation at the effector binding interface.

Fig 4

Schematic representation of the conformations adopted by Pikp-HMA (PDB: 6G11), Pikm-HMA (PDB: 6FUB) and Pikh-HMA at interface 3 in complex with AVR-PikE or AVR-PikC. In each panel, the effector is represented in cylinders, with the molecular surface also shown and coloured as labelled. Pik-HMA residues are coloured as labelled and shown as the Cα-worm. For clarity, only the Lys-261/262 side chain is shown. Hydrogen bonds between Lys-261/262 and the effector are represented by dashed black lines. (A) Pikp-HMA bound to AVR-PikE, (B) Pikh-HMA bound to AVR-PikC, (C) Pikm-HMA bound to AVR-PikE. (D) Superposition of HMA chains bound to AVR-Pik. For clarity, only the Lys-261/262 side chain is shown. Two different effector alleles, AVR-PikE and AVR-PikC, are represented by their molecular surface coloured in grey.