Table 1. Empirical sensitivity and specificity values used to inform distributions of sensitivity and specificity for confirmed and suspected cases.

Diagnostic criteria	Sensitivity	Specificity	Reference
Molecular—RT-PCR	0.87	0.95	[36]
Molecular—RT-PCR	0.82	0.96	[36]
Serological—Combined Euroimmun Zika virus IgM and IgG	0.82	0.69	[37]
Serological—Combined Dia.Pro Zika virus IgM and IgG	0.87	0.62	[37]
Serological—Euroimmun IgM test	0.49	0.99	[37]
Serological—Dia.Pro IgM test	0.69	0.96	[37]
Serological—ZIKV MAC-ELISA	0.94	0.309	[38]
Serological—ZIKV Detect IgM capture ELISA	1.0	0.925	[38]
Serological—Liaison XL Zika capture IgM assay	0.942	0.993	[38]
Serological—ADVIA Centaur Zika test	0.902	0.959	[38]
Serological—DPP Zika IgM system	0.951	0.982	[38]
Serological—Euroimmun IgM	0.32	0.97	[39]
Serological—Euroimmun IgM	0.54	0.97	[40]
Serological—Abcam IgM	0.57	0.97	[39]
Serological—Novatec IgM	0.65	0.54	[39]
Serological—Inbios IgM (ZIKV Detect)	1.0	0.74	[39]
Serological—MAC-ELISA with ZIKV PRNT positive	1.0	0.11	[41]
Serological—MAC-ELISA with ZIKV RT-PCR positive	0.14	1.0	[41]
Serological—MAC-ELISA with both sample types	0.82	0.72	[41]
Serological—Diasorin Liaison with ZIKV PRNT positive	0.85	0.56	[41]
Serological—Diasorin Liaison with ZIKV RT-PCR positive	0.29	1.0	[41]
Serological—Diasorin Liaison with both sample types	0.74	0.86	[41]
Serological—Zika Virus IgG/IgM Antibody Rapid Test	0.714	0.233	[42]
Clinical—PAHO-2015	0.813	0.109	[28]
Clinical—CDC-2016	1.0	0.014	[28]
Clinical—PAHO-2016	0.583	0.519	[28]
Clinical—ECDC-2016	0.809	0.580	[28]
Clinical—WHO-2016	0.756	0.635	[28]
Clinical—Brasil(MoH)-2016	0.286	0.973	[28]