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Glucose is differentially utilized in CD4 T cells and iNKT cells after stimulation. Activated CD4 T cells metabolize glucose primarily into lactate, whereas iNKT cells support the PPP and OXPHOS. Activated iNKT cells produce more ATP than CD4 T cells, which is likely due to elevated OXPHOS in iNKT cells. Abbreviations: ATP, adenosine triphosphate; PPP, pentose phosphate pathway; OXPHOS, oxidative phosphorylation.
