TABLE 5.
Sensitivity analysis showing factors associated with one or more RBC transfusions during inpatient hospitalizations in the 2016 Kids’ Inpatient Database (KID) for neonates (age ≤28 d) complicated births where the length of hospitalization stay was more than 3 days
| No. transfused (n = 10,387) | % transfused (2.71) | OR (95% CI) | p value | aOR (95% CI) | p value | |
|---|---|---|---|---|---|---|
| Sex | ||||||
| Male | 5,531 | 2.63 | Reference | … | Reference | … |
| Female | 4,854 | 2.80 | 1.07 (1.02–1.12) | 0.005 | 1.05 (1.00–1.11) | 0.062 |
| Race/Ethnicity | ||||||
| White | 3,288 | 1.94 | Reference | - | Reference | - |
| African American | 2,946 | 4.54 | 2.40 (2.15–2.68) | <0.001 | 1.88 (1.64–2.16) | <0.001 |
| Hispanic | 2,077 | 3.25 | 1.70 (1.47–1.96) | <0.001 | 1.51 (1.30–1.79) | <0.001 |
| Asian or Pacific Islander | 512 | 2.62 | 1.36 (1.09–1.69) | 0.006 | 1.44 (1.21–1.70) | <0.001 |
| Other | 723 | 2.62 | 1.26 (1.12–1.64) | 0.001 | 1.22 (1.00–1.49) | 0.058 |
| Length of stay (d)* | 1.04 (1.03–1.04) | <0.001 | 1.02 (1.02–1.02) | <0.001 | ||
| APR-DRG risk mortality subclass | ||||||
| 1 | 2,000 | 0.64 | Reference | … | Reference | … |
| 2 | 2,688 | 6.36 | 10.62 (9.76–11.55) | <0.001 | 6.89 (6.24–7.60) | <0.001 |
| 3 | 4,088 | 20.74 | 40.91 (36.68–45.61) | <0.001 | 16.00 (13.85–18.47) | <0.001 |
| 4 | 1,413 | 25.28 | 52.88 (45.25–61.80) | <0.001 | 18.06 (14.76–22.09) | <0.001 |
| APR-DRG risk severity subclass† | ||||||
| 1 | 160 | 0.14 | Reference | … | … | … |
| 2 | 1,216 | 0.89 | 6.31 (5.19–7.67) | <0.001 | … | … |
| 3 | 3,748 | 3.35 | 24.40 (20.15–29.55) | <0.001 | … | … |
| 4 | 5,065 | 24.65 | 230.50 (188.14–282.39) | <0.001 | … | … |
| Primary payer‡ | ||||||
| Medicaid | 27 | 2.47 | Reference | … | Reference | … |
| Medicare | 6,060 | 3.03 | 0.81 (0.47–1.40) | 0.447 | 1.27 (0.62–2.59) | 0.516 |
| Private | 3,766 | 2.37 | 0.78 (0.71–0.85) | <0.001 | 1.05 (0.95–1.17) | 0.320 |
| Self | 144 | 1.26 | 0.41 (0.32–0.53) | <0.001 | 0.76 (0.57–1.01) | 0.061 |
| No charge/other | 383 | 3.15 | 1.04 (0.80–1.35) | 0.775 | 0.91 (0.67–1.23) | 0.523 |
| In-hospital mortality† | ||||||
| No | 9,493 | 2.49 | Reference | … | … | … |
| Yes | 885 | 32.48 | 18.80 (16.41–21.55) | <0.001 | … | … |
| Hospital control† | ||||||
| Government, nonfederal | 1,740 | 3.42 | Reference | … | … | … |
| Private, nonprofit | 7,544 | 2.69 | 0.78 (0.60–1.01) | 0.062 | … | … |
| Private, investor-owned | 1,103 | 2.11 | 0.61 (0.42–0.88) | 0.009 | … | … |
| Hospital location/teaching‡ | ||||||
| Urban teaching | 9,054 | 3.07 | Reference | … | Reference | … |
| Urban nonteaching | 1,265 | 1.73 | 0.55 (0.44–0.70) | <0.001 | 0.99 (0.76–1.29) | 0.921 |
| Rural | 68 | 0.43 | 0.14 (0.06–0.29) | <0.001 | 0.41 (0.21–0.79) | 0.008 |
All data are weighted using survey weights provided by The Healthcare Cost and Utilization Project (HCUP). RBC transfusion defined as at least one RBC transfusion procedure, identified using International Classification of Diseases, 10th Revision codes: 30233 N1, 30233P1, 30243 N1, 30243P1, 30253 N1, 30263 N1, and/or 30623P1. Bold type refers to any p <0.05.
Data may not sum to 100% due to missingness.
Data are median and corresponding interquartile range (IQR) for admissions with one or more RBC transfusion.
Excluded from multivariable model due to high collinearity.
Medicare primary payer status and rural hospital data estimates have a coefficient of variation above the threshold of 30%.