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. Author manuscript; available in PMC: 2021 Jul 8.
Published in final edited form as: Science. 2021 Jan 7;371(6525):153–159. doi: 10.1126/science.abe3040

Fig. 1. Rapid social transfer of pain to bystander mice.

Fig. 1.

(A) Timeline of social transfer of pain protocol. (B) Timecourse of mechanical von Frey (VF) sensitivity at 0, 4, 24 and 48 h post 1h social interaction in Con/Con and CFA/BY pairs. (C) Mechanical thresholds immediately after the 1 h social interaction. (D) Mechanical thresholds of the ipsilateral vs. contralateral hindpaws. (E) Tail withdrawal latencies in the tail immersion test. (F) Time (%) spent on the warm floor (40° C) in the thermal place test (TPT). (G) Time (s) a stranger conspecific spent sniffing each group. Data are means ± s.e.m. Dotted lines (---) represents mean baseline thresholds for all groups (B, C, D); Statistical tests included two-way repeated measures (A), one-way (B, E, F, G) and two-way (D) ANOVA with Holm-Sidak post hoc tests; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 representative of post hoc comparisons. All statistical measure details are presented in Table S1A.