Table 1.

Apparent k_ex at all ligand concentrations calculated based on the fits to the subunit exchange data from experiment 1, experiment 2, and the combined data.

Kinetic Stabilizer	Concentration (μM)	apparent kex, Experiment 1 (h−1)	apparent kex, Experiment 2 (h−1)	apparent kex, Combined Experiments (h−1)
Tafamidis	0	0.0142	0.0140	0.0140
	1	0.0116	0.0115	0.0114
	5	0.0046	0.005	0.0046
	10	0.0020	0.0023	0.0020
	20	0.0008	0.0009	0.0008
	30	0.0004	0.0005	0.0004
AG10	0	0.0148	0.0164	0.0147
	1	0.0114	0.0129	0.0114
	5	0.0022	0.0037	0.0026
	10	0.0005	0.0012	0.0007
	20	0.0001	0.0004	0.0002
	30	0.0001	0.0002	0.0001
Tolcapone	0	0.0153	0.0157	0.0152
	1	0.0123	0.0127	0.0123
	5	0.0044	0.005	0.0045
	10	0.0017	0.0021	0.0018
	20	0.0007	0.0008	0.0007
	30	0.0004	0.0005	0.0004
Diflunisal	0	0.0156	0.0141	0.0155
	1	0.0153	0.0139	0.0151
	5	0.0142	0.0129	0.0139
	10	0.0129	0.0118	0.0126
	20	0.0109	0.0100	0.0104
	30	0.0093	0.0086	0.0088