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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Mol Cancer Ther. 2021 Mar;20(3):577–588. doi: 10.1158/1535-7163.MCT-20-0446

Figure 8. Efficacy of FIR and B7-H3 CAR T cell combinatorial therapy in inhibiting growth of a hormone insensitive PC3 PCa xenograft model is optimal when B7-H3 CAR T cells are administered 1-3 days post-FIR.

Figure 8

Schematic diagram of the experimental schedule (A), mean ± SEM of tumor volume (B) and body weight (C) are shown. At the time of sacrifice, the tumor from each mouse was collected. A single cell suspension from 2 pooled tissue samples (tumors from 5 mice of the same group were pooled into 2 pools: one pool consists of 2 and the other pool consists of 3 tissue samples) from each group was assessed by flow cytometry for ALDH+CD44+ PCSCs (D) and mean ± SD (%) of ALDH+CD44+ PCSCs is shown (E). Pools were also analyzed for sphere formation. Shown are representative photographs (x100) (F) and mean ± SD of spheres/well (G). *p <0.05; **<0.01; ***<0.001.