Table 3.
Individual study’s analytic specifications and effect sizes with standard error.
| Author | Total N | AB− n | AB + n | Amyloid scale | Amyloid method | SCD only | Covariate-controlled | Picture naming | Semantic fluency | Vocabulary | WAIS Information | Word-picture matching |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aizenstein et al. (2008) | 38 | 29 | 9 | categorical | PET | no | no | −0.51 (0.39) | −0.02 (0.38) | – | – | – |
| Amariglio et al. (2012) | 131 | 97 | 34 | categorical | PET | no | no | 0.26 (0.2) | – | – | – | – |
| Bennett et al. (2006) | 134 | 84 | 50 | categorical | histology | no | no | 0.44 (0.18) | 0.39 (0.18) | 0.05 (0.18) | – | – |
| Bos et al. (2018) | 907 | 526 | 190 | categorical | CSF or PET | no | no | – | 0.12 (0.08) | – | – | – |
| Clark et al. (2018) | 314 | 240 | 104 | categorical | CSF | no | no | – | 0.94 (0.14) | – | – | – |
| Doraiswamy et al. (2014) | 67 | 57 | 10 | categorical | PET | no | no | – | 0.4 (0.34) | – | – | – |
| Dubois et al. (2018) | 318 | 230 | 88 | categorical | PET | yes | no | −0.02 (0.13) | 0.14 (0.13) | – | – | – |
| Edelman et al. (2017) | 44 | 23 | 21 | categorical | PET | no | no | 0.34 (0.3) | 0.17 (0.3) | – | – | – |
| Edmonds et al. (2015) | 570 | 142 | 428 | categorical | CSF | no | no | 0.2 (0.09) | 0.22 (0.09) | – | – | – |
| Funaki et al. (2019) | 42 | 32 | 10 | categorical | PET | no | no | – | −0.07 (0.36) | – | – | – |
| Harrington et al. (2017) | 335 | 277 | 58 | categorical | PET | no | yes | – | 0.25 (0.14) | – | – | – |
| Hassenstab et al. (2016) | 264 | 177 | 87 | categorical | CSF | no | no | 0.14 (0.13) | 0.09 (0.13) | – | 0.13 (0.13) | – |
| Hilal et al. (2017) | 1201 | – | – | continuous | plasma | no | yes | – | 0.28 (0.33) | – | – | – |
| Hulette et al. (1998) | 11 | 7 | 4 | categorical | histology | no | no | – | 0.68 (0.64) | – | – | – |
| Jicha et al. (2012) | 126 | 71 | 54 | categorical | histology | no | no | – | 0.18 (0.18) | – | – | – |
| Kawas et al. (2013) | 13 | 9 | 4 | Categorical | PET | no | no | 0.56 (0.61) | 0.66 (0.61) | – | – | – |
| Kim et al. (2016) | 13 | 10 | 3 | continuous | PET | yes1 | no | 0.92 (0.68) | 0.51 (0.67) | – | – | – |
| Lee et al. (2020) | 97 | – | – | continuous | plasma | no | yes | 0.05 (0.21) | – | – | – | – |
| Li et al. (2007) | 72 | 51 | 21 | categorical | CSF | no | no | – | 0.52 (0.26) | – | – | – |
| Li et al. (2014) | 315 | – | – | continuous | CSF | no | yes | – | 0.1 (0.05) | – | – | – |
| Lim et al. (2013) | 178 | 123 | 55 | categorical | PET | yes | no | −0.1 (0.16) | – | – | – | – |
| Loewenstein et al. (2016) | 23 | – | – | continuous | PET | no | no | – | 0.93 (0.44) | – | – | – |
| Mathis et al. (2013) | 152 | 74 | 78 | categorical | PET | no | no | – | 0.14 (0.16) | – | – | – |
| Mielke et al. (2016) | 464 | 383 | 81 | categorical | PET | no | yes | −0.16 (0.24) | 0.05 (0.22) | – | – | – |
| Morris et al. (1996) | 21 | 12 | 9 | categorical | histology | no | no | 0.97 (0.47) | – | – | −0.18 (0.44) | – |
| Oh et al. (2011) | 52 | 33 | 19 | categorical | PET | no | no | 0.51 (0.29) | – | 0.41 (0.29) | – | – |
| Oh et al. (2012) | 189 | 34 | 18 | categorical | PET | no | no | – | −0.39 (0.29) | – | – | – |
| Papp et al. (2017) | 279 | 209 | 70 | categorical | PET | no | no | – | −0.09 (0.14) | – | – | – |
| Payoux et al. (2015) | 235 | 158 | 77 | categorical | PET | no | no | – | 0.24 (0.14) | – | – | – |
| Perrotin et al. (2012) | 48 | 27 | 11 | categorical | PET | no | no | – | 0.43 (0.36) | – | – | – |
| Price et al. (2009) | 97 | 59 | 38 | categorical | histology | no | no | −0.01 (0.21) | 0.17 (0.21) | – | – | – |
| Rami et al. (2011) | 17 | 11 | 6 | categorical | CSF | yes | no | 0.32 (0.51) | 0.86 (0.53) | – | – | – |
| Rosenberg et al. (2013) | 15 | – | – | continuous | PET | no | no | – | 0.37 (0.52) | – | – | – |
| Sala-Llonch et al. (2017) | 89 | 62 | 27 | categorical | CSF | no | no | – | 0.01 (0.23) | – | – | – |
| Snitz et al. (2020) | 118 | – | – | continuous | PET | no | yes | – | 0.07 (0.18) | – | – | −0.12 (.07) |
| Soldan et al. (2016) | 222 | 148 | 74 | categorical | CSF | no | no | 0 (0.14) | – | – | – | – |
| Sperling et al. (2013) | 78 | 60 | 18 | categorical | PET | no | no | – | 0.25 (0.27) | – | – | – |
| Um et al. (2017) | 50 | 34 | 16 | categorical | PET | no | no | −0.35 (0.31) | 0.21 (0.3) | – | – | – |
| Vannini et al. (2013) | 41 | 22 | 19 | categorical | PET | no | no | 0.96 (0.33) | – | – | – | – |
| Verberk et al. (2020) | 241 | – | – | continuous | CSF | yes | yes | −0.15 (0.08) | 0.03 (0.06) | – | – | – |
| Verfaillie et al. (2019) | 63 | 44 | 19 | categorical | PET or CSF | yes | no | −0.33 (0.28) | 0.11 (0.27) | – | – | – |
Note. SCD = subjective cognitive decline; PET = positron emission tomography, CSF = cerebrospinal fluid;
1
All subjects had a history of major depressive disorder in addition to SCD.