Table 2.
Demographic characteristics and test scores of 2,802 younger generation (born after 1935) LLFS participants.
| APOE2(ε2ε2, ε2ε3) | APOE3(ε3ε3) | APOE4(ε3ε4, ε4ε4) | p-value (t-test, comparing APOE2 and APOE3) | p-value (t-test, comparing APOE4 and APOE3) | |
|---|---|---|---|---|---|
| N | 419 | 1799 | 584 | ||
| Age at Enrollment, mean(SD), years | 59.1(7.3) | 59.8(7.2) | 60.1(6.7) | 0.08 | 0.30 |
| Age at visit 2, mean(SD), years | 67.1(7) | 67.8(6.9) | 68.2(6.6) | 0.13 | 0.29 |
| Gender, male(%) | 199(47.5%) | 774(43%) | 266(45.5%) | 0.10 | 0.29 |
| Education, college and above(%) | 229(54.7%) | 1027(57.1%) | 310(53.1%) | 0.37 | 0.09 |
| Deceased at follow up (%)a | 18(4.3%) | 95(5.3%) | 31(5.3%) | 0.38 | 0.98 |
| Test Scores at baseline (SD) | |||||
| MMSE | 28.9(2.5) | 29(1.8) | 28.8(2.6) | 0.52 | 0.18 |
| Animal Fluency | 22.3(5.9) | 22.5(5.9) | 22.4(5.4) | 0.43 | 0.70 |
| DSST | 52(12.4) | 51.7(12.2) | 50.4(11.8) | 0.59 | 0.03 |
| Digits Forward | 8.5(2.2) | 8.6(2.2) | 8.5(2.2) | 0.29 | 0.08 |
| Digits Backward | 6.8(2.3) | 6.9(2.4) | 6.6(2.2) | 0.81 | 0.02 |
| Logical Memory-Immediate | 13.3(3.9) | 13.4(3.9) | 13.2(4.1) | 0.57 | 0.29 |
| Logical Memory-Delayed | 11.9(4.2) | 12.1(4.2) | 11.8(4.5) | 0.49 | 0.24 |
| Test Scores at follow-up (SD) | |||||
| MMSE | 29.1(2) | 29.1(1.6) | 29.2(1.4) | 0.92 | 0.58 |
| Animal Fluency | 22.9(5.7) | 22.8(6.1) | 22.8(5.9) | 0.74 | 0.94 |
| DSST | 48.9(11.7) | 48.9(12) | 47.4(11.4) | 0.96 | 0.02 |
| Digits Forward | 7.7(2.7) | 7.7(2.5) | 7.6(2.5) | 0.85 | 0.33 |
| Digits Backward | 6.6(2.1) | 6.6(2.2) | 6.4(2.1) | 0.88 | 0.08 |
| Logical Memory-Immediate | 14.1(3.6) | 14.3(3.8) | 14.1(4.2) | 0.49 | 0.63 |
| Logical Memory-Delayed | 12.7(4.2) | 12.9(4.2) | 12.7(4.3) | 0.52 | 0.64 |
Notes: MMSE = Mini-Mental State Examination, DSST = Digit Span Substitution Test
a
Follow up from visit 1 through April 2018