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. 2021 Mar 1;47(5):70. doi: 10.3892/ijmm.2021.4903

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Schematic representation of the mechanism by which circNRIP1 promotes keloid progression. circNRIP1 induced pre-miR-503 maturation via protecting FXR1 from Fbxo4-mediated ubiquitination and degradation, which facilitated proliferation and extracellular matrix accumulation, but inhibited apoptosis, in keloid-derived fibroblasts. circNRIP1, circular nuclear receptor interacting protein 1; miR, microRNA; FXR1, Fbxo4-mediated FMR1 autosomal homolog 1; AGO2, argonaute RISC catalytic component 2.