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. 2021 Mar 2;47(5):73. doi: 10.3892/ijmm.2021.4906

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Regulation of aromatase promoters. The expression of aromatase is regulated by tissue-specific promoters, and the figure illustrates the distance between each specific promoter and the first exon II. Breast adipose stromal cells mainly express aromatase through the promoter I.4, while breast cancer tissue use 4 promoters (I.4, I.7, I.3 and II) to regulate aromatase, significantly increasing the expression level of aromatase mRNA and promoting local estrogen production. Endometrial cancer and ovarian cancer are mainly caused by PI.3 and PII, which also lead to a disruption in the expression of aromatase.