FIGURE 1.

Histopathology results 6–8 weeks C57/B6 mice, with or without Nrf2 knockout were exposed to either filtered air or air containing particulate matter (PM) for six or eleven weeks, and then the vascular tissue samples were fixed in 4% paraformaldehyde for 24 h, and then histologically processed for hematoxylin and eosin staining. The right vascular wall thickness was then measured and analyzed. N = 6 per group. WTC was C57 wild-type control group, WTE was C57 wild-type PM exposure group, KOC was Nrf2-/- group control group, and KOE was Nrf2-/- group PM exposure group. *: statistically different between the two groups (p < 0.05). (A): Representative hematoxylin and eosin stained sections for WT-C, WT-E, KO-C, and KO-E groups after 6- or 11-weeks treatment. Scale bars represent 1,000 um. (B): Quantification of the aorta wall thickness following 6-weeks. (C): Quantification of the aorta wall thickness following 11-weeks