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. 2021 Feb 26;12:618023. doi: 10.3389/fphar.2021.618023

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Copyright © 2021 Gao, Ma, Luo, Li, Jiang, Jiang, Pi, Chen, Chen, Zhang, Zheng and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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QRT-PCR Results 6–8 weeks C57/B6 mice, with or without Nrf2 knockout were exposed to either filtered air or air containing particulate matter (PM) for six weeks, and then the vascular tissues were collected, snap-frozen in liquid nitrogen. N = 3 per group. WTC was C57 wild-type control group, WTE was C57 wild-type PM exposure group, KOC was Nrf2-/- group control group, and KOE was Nrf2-/- group PM exposure group. *: statistically different between the two groups (p < 0.05). (A): Expression of ACE mRNA. (B): Expression of AGT mRNA. (C): Expression of AT1R mRNA. (D): Expression of HO-1 mRNA. (E): Expression of Nqo-1 mRNA. (F): Expression of Gclc mRNA. (G): Expression of Gsta-4 mRNA.