TABLE 3.
Relative expression of gene related to vascular injury *(Mean ± standard deviation).
| Genes | Groups | |||
|---|---|---|---|---|
| WTC | WTE | KOC | KOE | |
| Related to cholesterol, lipid formation and vascular calcification | ||||
| ABCA1 | 1.00 ± 0.00 | 1.03 ± 0.15 | 1.14 ± 0.08 | 1.05 ± 0.17 |
| Dag1 | 1.00 ± 0.00 | 1.12 ± 0.03 | 1.04 ± 0.10 | 1.11 ± 0.19 |
| BMP2 | 1.00 ± 0.00 | 1.01 ± 0.23 | 1.09 ± 0.09 | 0.99 ± 0.16 |
| Related to vascular smooth muscle proliferation and vascular endothelial injury | ||||
| TGFβ | 1.00 ± 0.00 | 0.92 ± 0.07 | 0.94 ± 0.11 | 1.02 ± 0.16 |
| AKT1 | 1.00 ± 0.00 | 1.12 ± 0.15 | 0.97 ± 0.15 | 1.08 ± 0.29 |
| MAPK | 1.00 ± 0.00 | 0.99 ± 0.12 | 0.91 ± 0.31 | 1.04 ± 0.10 |
| DDIT3 | 1.00 ± 0.00 | 0.93 ± 0.11 | 1.13 ± 0.19 | 1.02 ± 0.22 |
| PRKCB | 1.00 ± 0.00 | 0.94 ± 0.12 | 1.10 ± 0.31 | 0.98 ± 0.52 |
| PPP2CB | 1.00 ± 0.00 | 1.06 ± 0.23 | 0.77 ± 0.13 | 1.03 ± 0.28 |
* Values are mean ± SD. WTC was C57 wild-type control group, WTE was C57 wild-type PM exposure group, KOC was Nrf2-/- group control group, and KOE was Nrf2-/-group PM exposure group. There is no statistical difference in the expression of the above genes (p > 0.05).