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. 2021 Feb 26;8:566678. doi: 10.3389/fmed.2021.566678

Table 3.

Therapeutic management of TMA patients.

Treatment, n (%) Primary TMA Secondary TMA
All TTP aHUS tHUS HELLP syndrome Malignant HBP Malignancies Drugs Infections AID aGVHD Others
n = 216 n = 12 n = 8 n = 8 n = 79 n = 12 n = 30 n = 11 n = 5 n = 5 n = 16 n = 30
Plasma exchange 40 (18.5) 9 (75.0) 6 (75.0) 6 (75.0) 0 (0) 1 (8.3) 5 (16.6) 3 (27.3) 2 (40.0) 3 (60.0) 1 (6.25) 4 (13.3)
Plasma infusion 30 (13.9) 2 (16.6) 2 (25.0) 2 (25.0) 10 (12.7) 0 (0) 3 (10.0) 3 (27.3) 0 (0) 0 (0) 2 (12.5) 6 (20.0)
PE or PI 61 (28.2) 9 (75.0) 6 (75.0) 6 (75.0) 10 (12.7) 1 (8.3) 6 (20.0) 6 (54.5) 2 (40.0) 3 (60.0) 3 (18.8) 9 (30.0)
Eculizumab 8 (3.7) 1 (8.3) 3 (37.5) 2 (20.0) 0 (0) 0 (0) 1 (3.3) 1 (9.1) 0 (0) 0 (0) 0 (0) 0 (0)
Rituximab 17 (7.9) 6 (50.0) 1 (12.5) 0 (0) 0 (0) 0 (0) 3 (10.0) 0 (0) 0 (0) 2 (40.0) 4 (25.0) 1 (3.3)
Red blood cell transfusion 94 (43.5) 8 (66.7) 4 (50.0) 4 (50.0) 14 (17.7) 6 (50.0) 19 (63.3) 5 (45.4) 2 (40.0) 4 (80.0) 15 (93.8) 13 (43.3)
Platelet transfusion 49 (22.7) 3 (25.0) 1 (12.5) 1 (12.5) 7 (8.9) 1 (8.3) 12 (40.0) 5 (45.4) 0 (0) 0 (0) 14 (87.5) 5 (16.6)
Dialysis (during first admission) 51 (23.6) 3 (25.0) 6 (75.0) 3 (37.5) 6 (7.59) 10 (83.3) 5 (16.7) 3 (27.3) 3 (60.0) 2 (40.0) 2 (12.5) 8 (26.7)