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. 2021 Feb 26;12:646023. doi: 10.3389/fphys.2021.646023

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Copyright © 2021 Williams, Roney, Connolly, Sim, Whitaker, O’Hare, Kotadia, O’Neill, Corrado, Bishop, Niederer, Wright, O’Neill and Linton.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of the site of earliest activation. (A) Example activation map showing the site of earliest activation, defined as the earliest local activation time recorded by Carto shown in red, and the site of earliest activation using the OpenEP percentile method shown in blue. (B) Relationship between Carto earliest activation sites and OpenEP earliest activation sites for all 40 cases. The Carto-defined earliest activation sites are shown with red spheres and the OpenEP-defined earliest activation sites are shown with blue spheres. The connecting lines indicate the pairing of data points on a case-by-case basis. LAO, left anterior oblique; LAT, local activation time.