. 2021 Mar 11;12(3):257. doi: 10.1038/s41419-021-03522-0

Table 1.

The tumorigenicity of α2δ1⁺ and α2δ1⁻ cells of NSCLC in NOD/SCID mice.

Tumor cells	α2δ1	Tumor formation		Frequency of tumorigenic cells (95% CI)	P value
Tumor cells	α2δ1	1000	100	Frequency of tumorigenic cells (95% CI)	P value
A549	Negative	2/5	0/5	1/2213 (1/8821–1/555)	2.60E−05^c
	Positive	5/5	4/5	1/62 (1/185–1/21)
	ST	5/5	4/5	1/62 (1/185–1/21)
H292	Negative	1/5	0/5	1/4983 (1/35191–1/706)	2.28E−06^c
	Positive	5/5	4/5	1/62.1 (1/185–1/21)
	ST	5/5	4/5	1/62.1 (1/185–1/21)
H520	Negative	1/5	0/5	1/4983 (1/35191–1/706)	0.0383^c
	Positive	3/5	2/5	1/ 711 (1/1928–1/263)
	ST	5/5	3/5	1/109 (1/348–1/34)
7494^a	Negative	0/3	0/3	N.A.
7494^a	Positive	3/3	3/3	N.A.
9157^a	Negative	0/3	0/3	N.A.
9157^a	Positive	0/3	0/3	N.A.
0296^a	Negative	0/1	0/1	N.A.
0296^a	Positive	1/1	0/1	N.A.
7470^b	Negative	1/5	0/5	1/4983 (1/35191–1/706)	0.09^c
7470^b	Positive	3/5	1/5	1/921 (1/2617–1/324)	0.09^c
9613^b	Negative	1/5	0/5	1/4983 (1/35191–1/706)	0.038^c
9613^b	Positive	3/5	2/5	1/711 (1/1928–1/263)	0.038^c

N.A. not applied, The calculation of TIC frequencies is not applicable because there are too few animals transplanted, ST serial transplantation.

^aPrimary NSCLC tissue.

^bNSCLC PDX tissues.

^cCompared between the α2δ1⁺ and α2δ1⁻subpopulations.