Table 2.
The tumorigenicity of indicated cells with α2δ1 knockdown or overexpression.
| Group | Tumor fromation | Frequency of Tumorigenic cells (95% CI) | P value | |
|---|---|---|---|---|
| 1000 | 100 | |||
| α2δ1+ A549 Scramble | 5/5 | 4/5 | 1/62 (1/185–1/21) | |
| α2δ1 shRNA1 | 3/5 | 2/5 | 1/712 (1/1928–1/263) | 0.002 |
| α2δ1 shRNA2 | 2/5 | 1/5 | 1/1445 (1/4728–1/442) | 9.63E–05 |
| α2δ1+ H520 Scramble | 5/5 | 2/5 | 1/184 (1/609–1/56) | |
| α2δ1 shRNA1 | 2/5 | 0/5 | 1/2212 (1/8821–1/555) | 0.0031 |
| α2δ1 shRNA2 | 3/5 | 0/5 | 1/1268 (1/3956–1/407) | 0.0159 |
| α2δ1− A549 Vector | 2/5 | 1/5 | 1/1445 (1/4728–1/442) | |
| α2δ1-OE | 5/5 | 4/5 | 1/62 (1/185–1/21) | 9.63E–05 |
| α2δ1− H520 Vector | 2/5 | 0/5 | 1/2212 (1/8821–1/555) | |
| α2δ1-OE | 4/5 | 2/5 | 1/452 (1/1205–1/170) | 0.0428 |
OE, overexpression.