Skip to main content
. 2021 Feb 26;12:616305. doi: 10.3389/fimmu.2021.616305

Figure 2.

Figure 2

(A) Variation in adhesion marker expression between the participants and monocyte subsets. Monocyte subset adhesion molecules, CD11b, CD49d (integrins) and chemokine receptor, CXCR2 expression. Each line on the graph is representative of relative adhesion marker expression from one participant. Participants with the highest marker expression were ranked based on monocyte subsets expressing the highest, CD11b, CD49d, and CXCR2. Red lines show participants with highest CD11b, CD49d, and CXCR2 expression (n = 10), green lines show participants with intermediate CD11b, CD49d, and CXCR2 expression (n=10) and blue lines show participants with lowest geometic mean fluoroscence intensity (MFI), CD11b, CD49d, and CXCR2 expression (n=10). C: Classical; I: intermediate and NC: non-classical. (B) Relationship between adhesion molecule expression by the monocyte subsets. Expression of CD11a (all p < 0.001; n=30), CD44 (all p < 0.001; n=30) and CCR2 (C- p < 0.001; n = 30). Data presented as scatter plots. The statistical significance of correlation was determined by Spearman’s rank correlation. All tests were two tailed. r represents correlation coefficient and p represents the statistical significant value. (C) Heatmap with correlation matrix. Panel 1: Classical monocytes, 2: Intermediate monocytes and 3: Non-classical monocytes. For all heatmaps, values are Spearman’s rank correlation coefficients. The color in the heatmap represents the degree of correlation. Red (value of 1) represents a stronger correlation coefficient and more significant p value. Yellow (value of 0.362) represents a moderate correlation coefficient and p value of 0.05 or less. White boxes represent non-significant correlations.