Table 4.
The validated candidate drugs by CMAP analysis
| Drug | Degree | UP | DOWN |
|---|---|---|---|
| PACLITAXEL | 4 | ARL4D, NUP214, LARP7, NEK9, C20ORF27, TOR1AIP1 | POLA1, CCNE1, BSG, FKBP10, GTF2F2, HMOX1 |
| DAUNORUBICIN | 3 | PCM1, NLRX1, C20ORF27, HMOX1 | PLEKHF2, TIMM9, PRIM1, CLIP4 |
| VORINOSTAT | 3 | SLC9A3R1, ATP6V1A, KDELC1, NEU1, ARL4D, ERO1LB, PDE4DIP | CCND1, H2AFY2, ZC3H7A, CDKN1B, USP13, MEPCE |
| DOXORUBICIN | 2 | FKBP10, TPSB2, ARL4D | PLEKHF2, DNAJB1 |
| DEXAMETHASONE | 2 | GSK3A, BRF1, C20ORF27, NUP214, HOOK1, POR | FKBP10, NLRX1, TRIM25, LCP1, HMOX1, RALA, SLC46A3, NPTX1 |
| IRINOTECAN | 2 | BRD2, NGDN | GSK3B, TIAM1 |
| DIETHYLSTILBESTROL | 2 | ERO1LB, CEACAM5, ALB, INHBE, CLIP4 | FOXRED2, PLOD2, POLA1, PLD3, NOL10 |
| DECITABINE | 2 | ERP44, | FKBP10, |
| IFOSFAMIDE | 2 | NEK9, RAB2A, LOX, | FKBP10, RCAN3, |
| SIROLIMUS | 2 | G3BP1, DIDO1, AKAP8L, SUN2, DDAH2, CEACAM5, CEP68, SIGMAR1, NUP88, PDE4DIP, ITGB1, NOL10, POFUT1, NLRX1, FKBP10, F2RL1, ERP44, COL6A1, IFIH1, BRF1, TAPT1, IKBKB, SCARB1, DPY19L1, SMAD3, LOX, SIRT5, CHPF, NEK9, SMAD3, HMOX1, ERMP1, POFUT1, PDE4DIP, PRIM2, | CCNE1, FOXRED2, SUN2, CHEK2, POR, CHPF, RALA, GOLGA3, FKBP10, DDX58, PRKAR2B, TIMM9, CCDC86, SGTA, TRIM25, NMB, FASTKD5, ERO1LB, STC2, VPS11, HMOX1, DDX10, NOL10, RRP9, SIL1, |
| PROCAINE | 2 | G3BP1, NUP88, MASP2 | SLC46A3, SLC9A3R1, PLD3 |
Each row demonstrates the drug with related degree in obtained gene-drug network along with affected up-regulated and down-regulated genes