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. 2021 Mar 11;11:5714. doi: 10.1038/s41598-021-85128-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Targeted region of MinION sequencing. (a) Diagram of the targeted region locus on chromosome 11 containing the HBB gene selected for this study was indicated by the red vertical line. (b and c) Long-range PCR strategy used for haplotyping. PCR amplicons of 10 kb and 20 kb libraries was indicated in (b,c) respectively. 10 kb or 20 kb PCR amplicons were designed overlapped and each horizontal line represents an amplicon. (d,e) The depth distribution and the coverage of sequencing data in the whole targeted region. Examples of the depth distribution of targeted region by MinION sequencing for 10 kb and 20 kb libraries was indicated in (d,e) respectively. The horizontal axis represents the position on chromosome 11. The vertical axis represents sequencing depth.