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. 2021 Mar 11;11:5709. doi: 10.1038/s41598-021-85319-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Morphology of Case 1. (A) Typical GCTB with osteoclastic giant cells and intermingled mononuclear cells before therapy (bar = 100 µm). Neoplastic mononuclear cells are positive in a H3F3A G34W staining in the nuclei (B) and about 5% of cells are Ki-67 positive (C). After denosumab therapy GCTB shows induction of neoformated osteoid and complete reduction of giant cells (D), while H3F3A G34W-positive cells are still present (E); insert shows H3F3A-negative spindle cells. Proliferation has dropped to 1% in a Ki67 staining (F).