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. 2021 Mar 11;11:5709. doi: 10.1038/s41598-021-85319-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Morphology of Case 2. Typical morphology of GCTB with osteoclastic giant cells and mononuclear spindle cells (A) neoplastic mononuclear cells with positive H3F3A G34W staining (B) (bar = 100 µm). Staining for Ki-67 shows about 5% positive cells (C). The sarcoma showed presents with polymorphic tumor cells andatypical mitotic figures with necrosis intermingled lace-like neoplastic osteoid intermingled with necrotic bone. An atypical mitotic figure is shown in the insert (D). The sarcoma harboured the H3F3A G34W mutation (E) and had a high rate of Ki-67 (F).