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. 2021 Mar 11;12(3):260. doi: 10.1038/s41419-021-03545-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — HCC cell lines, MHCC-97H, and Huh-7, were cultured in control medium (Control), NFs-derived conditioned medium (NFs-CM), CAFs-derived conditioned medium (CAFs-CM), CAFs-CM added with PBS (CAFs-CM/PBS), CAFs-CM added with 5 ng/ml CXCL11 (CAFs-CM/CXCL11 (5 ng/ml)), CAFs-CM added with 10 ng/ml CXCL11 (CAFs-CM/CXCL11 (10 ng/ml)), CAFs-CM added with IgG (CAFs-CM/IgG), and CAFs-CM added with anti-CXCL11 (CAFs-CM/anti-CXCL11). A The morphological changes of HCC cell line MHCC-97H were examined by scanning electron microscopy (SEM) with different magnifications; red arrows indicated the pseudopodia of HCC cells. B HCC cells viability was determined by MTT assays. C HCC cell DNA synthesis ability was determined by EDU assay. D HCC cell migration was examined using Transwell assay. E HCC cell migration was examined by wound healing assay. F The protein levels of Vimentin and Twist was examined by Immunoblotting. *P < 0.05, **P < 0.01, compared with the control group; ^#P < 0.05, ^##P < 0.01, compared with the NFs-CM group; ^$P < 0.05, ^$$P < 0.01, compared with the CAFs-CM/PBS group; ^&P < 0.05, ^&&P < 0.01, compared with the CAFs-CM/IgG group.