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. 2021 Mar 11;11:5659. doi: 10.1038/s41598-021-84894-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Global and hepatocyte-specific deletion of Atp7b have different impact on lipid metabolism. (a) The representative H&E staining of liver section illustrates the development of steatosis in Atp7b^ΔHep-B6 animals (ΔHep), in agreement with the previous reports (²¹); (b) the lack of liver steatosis in Atp7b^−/−-B6 and Atp7b^-/–hybrid mice (males and females). (c) Triglyceride concentrations in the livers of Atp7b−/− hybrid (Hybrid) and Atp7b^-/–B6 (B6) mice. The one-way ANOVA was used for statistical analysis *p value ≤ 0.05 was considered statistically significant, p > 0.05 is not statistically significant, (ns). “Ctrl”—control group—included wild-type and heterozygous animals on the corresponding genetic background.