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. 2021 Mar 11;11:5659. doi: 10.1038/s41598-021-84894-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the altered pathways in Atp7b^ΔHep-B6 and Atp7b^-/–B6 livers using Ingenuity Pathway Analysis (IPA). (a) The most significantly changed pathways (|Z| score > 2.5 for Atp7b^-/–B6 animals and > 2.3 for Atp7b^ΔHep-B6 pathways. The data were generated using samples analyzed within the same mass-spectrometry run; n = 3 per each genotype. Orange color indicates the upregulated pathways and blue color – down-regulated pathways. The complete list of affected pathways is given in Suppl Table 4 and Suppl Table 5. (b) Components of the respiratory chain in mitochondria that are significantly changed in response to Cu accumulation in Atp7b^ΔHep-B6 and Atp7b^-/–B6 mice. Upregulated proteins are labeled in red, down-regulated proteins are in green. Data generated and visualized using IPA (https://digitalinsights.qiagen.com/products-overview/discovery-insights-portfolio/analysis-and-visualization/qiagen-ipa/).