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. 2021 Mar 11;11:5749. doi: 10.1038/s41598-021-84852-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Delivery of CoQ10 into mitochondria by BPM31510 affects total respiration in MIA PaCa-2 and PANC1. (a) Dose effect of BPM31510 on total respiration in MIA PaCa-2 and PANC1 cells. State 3 respiration on pyruvate/malate + succinate + glycerol-3-phosphate of cells exposed to BPM31510 at 24 h. The data represent the means ± SEM of three independent experiments with five replicates (n = 15). (b) Fluorescently tagged CoQ₁₀ (red) from BPM31510 (200 μM) colocalized with the mitochondria (MitoTracker; green) in MIA PaCa-2 and PANC1 cells after 24 h exposure. (c) BPM31510 treatment increased the total CoQ₁₀ levels in MIA PaCa-2 and PANC1 cells as measured by LC MS/MS after 24 h and 48 h exposures. The data represent the means + SEM of total protein (nmol/mg) from six independent experiments. The data were analysed by Student’s t tests; ****=p < 0.0001 compared to untreated control; ⁺⁺=p < 0.01 compared to the 24 h time point. The scale bar present in each merged image represents 10 mM.