Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 11;11:5749. doi: 10.1038/s41598-021-84852-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

BPM31510 decreases Q-pool linked Complex II and mitochondrial glycerol-3-phosphate dependent respiration, resulting in shifts in respiratory dependency of specific mitochondrial complexes. (a) State 3 respiration on pyruvate/malate + succinate + glycerol-3-phosphate in MIA PaCa-2 and PANC1 cells after BPM31510 treatment. (b) Effects of BPM31510 on electron transport chain complex (substrate-specific) respiration in MIA PaCa-2 and PANC1 cells. The data represent the means + SEM of three independent experiments. (c) BPM31510 shifts respiratory dependency in MIA PaCa-2 and PANC1 cells. Complex-specific respiration was assessed as described in the Methods section. The data report the percentage of total respiration. The data represent the means + SEM of three independent experiments. The data were analysed by Student’s t-tests; ***p < 0.001 compared to untreated cells.