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. 2021 Mar 11;11:5749. doi: 10.1038/s41598-021-84852-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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BPM31510 affects tumour size and alters mitochondrial respiration in vivo in a MIA PaCa-2 xenograft mouse model of pancreatic cancer. (a) BPM31510 (25 mg/kg, i.p., B.I.D.) effects on tumour volume in an MIA PaCa-2 xenograft pancreatic mouse model. Representative tumours from an untreated control and BPM31510-treated mouse are shown (inset). The data were analysed by Student’s t test; *p < 0.05 compared to control mice. (b) CoQ₁₀ levels in tumours after BPM31510 treatment. Data represent n = 11 saline-treated mice and n = 12 BPM31510-treated mice. Data were analysed by Student’s t test. *p < 0.05 vs control. (c,d) BPM31510 effects on (c) state 3 G3PDH respiration and (d) state 3 Complex II respiration in MIA PaCa-2-derived epithelial cancer cells enriched from excised xenografts. N = 6 per group. The data represent the means + SEM and were analysed by a Mann–Whitney non-parametric test; ****p < 0.0001 compared to saline.