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. 2021 Feb 26;9:604899. doi: 10.3389/fped.2021.604899

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Copyright © 2021 Pantalone, Liu, Olaloye, Prochaska, Yanowitz, Riley, Buland, Brozanski, Good and Konnikova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in peripheral cell counts in infants <33 weeks (A–D) and ≥33 weeks (E–H) at the end of antibiotic treatment. Median absolute levels of monocytes (A), lymphocytes (C), neutrophils (E), and bands (G) are plotted at baseline, NEC diagnosis, and the end of the antibiotic course (End Abx). Tukey boxplots for percent changes in monocytes (B), lymphocytes (D), neutrophils (F), and bands (H) at end of antibiotics compared with NEC diagnosis. Bars represent 25 and 75% percentiles (A,C,E,G) or 1.5× the IQR (B,D,F,H). *Significance for absolute cell count; *p < 0.05, **p < 0.01. *Significance for percent change; *p < 0.05. °Indicates outliers (>1.5 × IQR) and ^xindicates extreme outliers (>3 × IQR).