TABLE 4.

Binding free energy (kcal/mol) approximation of drug molecules (Tellimagrandin I, SaikosaponinB2, Hesperidin, and (-)-Epigallocatechin Gallate) against RNA dependent RNA polymerase (RdRp).

Compounds	∆Gbinding	∆EvdW	∆Eelectrostatic	∆EGB	∆ESURF	∆Ggas	∆Gsolv
Tellimagrandin I	−32.43 ± 3.06	−48.45 ± 2.65	−12.64 ± 4.14	34.41 ± 3.94	−5.75 ± 0.19	−61.10 ± 4.88	28.66 ± 3.93
SaikosaponinB2	−42.43 ± 3.25	−64.57 ± 2.33	−26.24 ± 3.16	56.38 ± 6.15	−7.99 ± 0.23	−90.81 ± 7.52	48.38 ± 6.11
Hesperidin	−22.72 ± 3.64	−37.35 ± 2.64	−24.56 ± 5.70	44.06 ± 5.04	−4.87 ± 0.29	−61.91 ± 6.26	39.19 ± 4.96
(-)-Epigallocatechin gallate	−24.17 ± 2.73	−39.95 ± 2.18	−4.96 ± 0.23	25.97 ± 5.95	−5.23 ± 0.36	−44.91 ± 6.76	20.73 ± 3.80