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Planar cell polarity and polycystic kidney disease. (A) Upregulation of transcripts of proteins involved in PCP (shown in the white box) have been detected in kidney lysates from paediatric patients with autosomal recessive polycystic kidney disease (PKD). (B) In mouse models of PKD, opposing epithelial cells lining cysts express VANGL1 and FZD6; suggestive that PCP may be active during cyst expansion.
