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. 2021 Mar 11;11:5696. doi: 10.1038/s41598-021-85086-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of GRB2 expression on survival. (A) Recurrence-free survival curves for prostate cancer patients in the TCGA dataset. Each population was divided into two groups according to the cutoff point defined by Cox regression model (cutoff z-score = 1.0951). (B) Representative images of prostate cancer biopsy samples showing low (top) or high (bottom) expression of GRB2 protein. C and D. Recurrence-free survival curves for prostate cancer patients in the local clinical cohort. Each population was divided into two groups according to the cutoff point defined by the Cox regression model (cutoff H-score = 69.8592) (C) and a z-score = 1 (D).