Table 3.
Association of time period with the number of positive lymph nodes in patients with vulvar squamous cell carcinoma living in northern Italy.
| Decade | Number of positive lymph nodes | |||||
|---|---|---|---|---|---|---|
| 0–1 (n = 392) | ≥ 2 (n = 138) | Odds ratio (95% CI)a | 0–2 (n = 441) | ≥ 3 (n = 89) | Odds ratio (95% CI)a | |
| 1980s | 56 | 22 (28.2) | 1.00 (reference category) | 62 | 16 (20.5) | 1.00 (reference category) |
| 1990s | 80 | 37 (31.6) | 1.36 (0.68–2.72) | 94 | 23 (19.7) | 1.08 (0.50–2.33) |
| 2000s | 129 | 43 (25.0) | 0.86 (0.44–1.65) | 142 | 30 (17.4) | 0.82 (0.40–1.69) |
| 2010s | 127 | 36 (22.1) | 0.67 (0.34–1.31) | 143 | 20 (12.3) | 0.53 (0.25–1.13) |
| P = 0.12b | P = 0.064b | |||||
Analysis was restricted to patients undergoing lymph node dissection (n = 530).
aSimultaneously adjusted for patient age, tumour size, disease location, depth of stromal invasion and number of lymph nodes dissected.
bChi-square test for trend. CI, confidence interval.